James A. Hamilton, PhD
Title Professor
Institution Boston University School of Medicine
Department Physiology & Biophysics
Address 700 Albany St CABR
Boston, MA 02118
Telephone (617) 638-5048
Email
Other Positions
Title Graduate Faculty (Primary Mentor of Grad Students)
Institution Boston University School of Medicine
Department Graduate Medical Sciences, Division of
 
Title Professor
Institution Boston University School of Medicine
Department Radiology
 
Title Research Associate Professor
Institution Boston University School of Medicine
Department Biochemistry
 
Title Research Associate Professor
Institution Boston University School of Medicine
Department Medicine
Division General Internal Medicine
 
Institution Boston Medical Center
Research Expertise & Professional Interests
Research in our group is aimed at providing fundamental information relating to heart disease, diabetes, obesity, and diseases related to fatty acid metabolism. An overall goal to is to develop novel approaches to biomedical issues by integrating physical-chemical and physiological/biochemical approaches. In our newer research this is achieved by assembling multi-disciplinary teams to translate basic research into clinical applications. We use physical and instrumental methods (including solution state 13C NMR spectroscopy, solid state and magic angle spinning multinuclear NMR, multidimensional NMR, MR imaging, and fluorescence) that are tailored to the specific questions we are addressing. These techniques are complemented with molecular modeling, molecular biology and other cell biology methods.
Publications
1. Krenzel ES, Chen Z, Hamilton JA. Correspondence of Fatty Acid and drug binding sites on human serum albumin: a two-dimensional nuclear magnetic resonance study. Biochemistry. 2013 Mar 5; 52(9):1559-67.
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2. Phinikaridou A, Hua N, Pham T, Hamilton JA. Regions of low endothelial shear stress colocalize with positive vascular remodeling and atherosclerotic plaque disruption: an in vivo magnetic resonance imaging study. Circ Cardiovasc Imaging. 2013 Mar 1; 6(2):302-10.
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3. Hayashi C, Papadopoulos G, Gudino CV, Weinberg EO, Barth KR, Madrigal AG, Chen Y, Ning H, Lavalley M, Gibson FC, Hamilton JA, Genco CA. Protective Role for TLR4 Signaling in Atherosclerosis Progression as Revealed by Infection with a Common Oral Pathogen. J Immunol. 2012 Oct 1; 189(7):3681-8.
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4. Phinikaridou A, Qiao Y, Giordano N, Hamilton JA. Detection of thrombus size and protein content by ex vivo magnetization transfer and diffusion weighted MRI. J Cardiovasc Magn Reson. 2012; 14:45.
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5. Cai J, Lücke C, Chen Z, Qiao Y, Klimtchuk E, Hamilton JA. Solution structure and backbone dynamics of human liver Fatty Acid binding protein: Fatty Acid binding revisited. Biophys J. 2012 Jun 6; 102(11):2585-94.
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6. Qiao Y, Hallock KJ, Hamilton JA. Magnetization transfer magnetic resonance of human atherosclerotic plaques ex vivo detects areas of high protein density. J Cardiovasc Magn Reson. 2011; 13:73.
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7. Anderson SW, Jara H, Ozonoff A, O'Brien M, Hamilton JA, Soto JA. Effect of disease progression on liver apparent diffusion coefficient and T(2) values in a murine model of hepatic fibrosis at 11.7 Tesla MRI. J Magn Reson Imaging. 2012 Jan; 35(1):140-6.
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8. Souza SL, Hallock KJ, Funari SS, Vaz WL, Hamilton JA, Melo E. Study of the miscibility of cholesteryl oleate in a matrix of ceramide, cholesterol and fatty acid. Chem Phys Lipids. 2011 Oct; 164(7):664-71.
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9. Phinikaridou A, Hamilton JA. Application of MRI to detect high-risk atherosclerotic plaque. Expert Rev Cardiovasc Ther. 2011 May; 9(5):545-50.
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10. Anderson SW, Soto JA, Milch HN, Ozonoff A, O'Brien M, Hamilton JA, Jara HJ. Effect of disease progression on liver apparent diffusion coefficient values in a murine model of NASH at 11.7 tesla MRI. J Magn Reson Imaging. 2011 Apr; 33(4):882-8.
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11. Hayashi C, Viereck J, Hua N, Phinikaridou A, Madrigal AG, Gibson FC, Hamilton JA, Genco CA. Porphyromonas gingivalis accelerates inflammatory atherosclerosis in the innominate artery of ApoE deficient mice. Atherosclerosis. 2011 Mar; 215(1):52-9.
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12. Liu Y, Atkinson D. Enhancing the Contrast of ApoB to Locate the Surface Components in the 3D Density Map of Human LDL. J Mol Biol. 2011 Jan 7; 405(1):274-83.
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13. Simard JR, Meshulam T, Pillai BK, Kirber MT, Brunaldi K, Xu S, Pilch PF, Hamilton JA. Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity. J Lipid Res. 2010 May; 51(5):914-22.
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14. Phinikaridou A, Ruberg FL, Hallock KJ, Qiao Y, Hua N, Viereck J, Hamilton JA. In vivo detection of vulnerable atherosclerotic plaque by MRI in a rabbit model. Circ Cardiovasc Imaging. 2010 May; 3(3):323-32.
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15. Guo Y, Tan LJ, Lei SF, Yang TL, Chen XD, Zhang F, Chen Y, Pan F, Yan H, Liu X, Tian Q, Zhang ZX, Zhou Q, Qiu C, Dong SS, Xu XH, Guo YF, Zhu XZ, Liu SL, Wang XL, Li X, Luo Y, Zhang LS, Li M, Wang JT, Wen T, Drees B, Hamilton J, Papasian CJ, Recker RR, Song XP, Cheng J, Deng HW. Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis. PLoS Genet. 2010; 6(1):e1000806.
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16. Brunaldi K, Huang N, Hamilton JA. Fatty acids are rapidly delivered to and extracted from membranes by methyl-beta-cyclodextrin. J Lipid Res. 2010 Jan; 51(1):120-31.
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17. Miller J, Agarwal A, Devi LA, Fontanini K, Hamilton JA, Pin JP, Shields DC, Spek CA, Sakmar TP, Kuliopulos A, Hunt SW. Insider access: pepducin symposium explores a new approach to GPCR modulation. Ann N Y Acad Sci. 2009 Nov; 1180 Suppl 1:E1-12.
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18. Ruberg FL, Chen Z, Hua N, Bigornia S, Guo Z, Hallock K, Jara H, LaValley M, Phinikaridou A, Qiao Y, Viereck J, Apovian CM, Hamilton JA. The relationship of ectopic lipid accumulation to cardiac and vascular function in obesity and metabolic syndrome. Obesity (Silver Spring). 2010 Jun; 18(6):1116-21.
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19. Pillai BK, Jasuja R, Simard JR, Hamilton JA. Fast diffusion of very long chain saturated fatty acids across a bilayer membrane and their rapid extraction by cyclodextrins: implications for adrenoleukodystrophy. J Biol Chem. 2009 Nov 27; 284(48):33296-304.
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20. Getty-Kaushik L, Viereck JC, Goodman JM, Guo Z, LeBrasseur NK, Richard AM, Flanagan JN, Yaney GC, Hamilton JA, Tornheim K. Mice deficient in phosphofructokinase-M have greatly decreased fat stores. Obesity (Silver Spring). 2010 Mar; 18(3):434-40.
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21. Guo W, Wong S, Pudney J, Jasuja R, Hua N, Jiang L, Miller A, Hruz PW, Hamilton JA, Bhasin S. Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir. Arterioscler Thromb Vasc Biol. 2009 Dec; 29(12):2028-32.
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22. Dohadwala MM, Vita JA. Grapes and cardiovascular disease. J Nutr. 2009 Sep; 139(9):1788S-93S.
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23. Tu P, Bhasin S, Hruz PW, Herbst KL, Castellani LW, Hua N, Hamilton JA, Guo W. Genetic disruption of myostatin reduces the development of proatherogenic dyslipidemia and atherogenic lesions in Ldlr null mice. Diabetes. 2009 Aug; 58(8):1739-48.
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24. Decano JL, Viereck JC, McKee AC, Hamilton JA, Ruiz-Opazo N, Herrera VL. Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein. Circulation. 2009 Mar 24; 119(11):1501-9.
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25. Nguyen HG, Korach A, Collura C, Eskenazi BR, Vita JA, Shapira OM. Differential effects of natriuretic peptides on arterial and venous coronary artery bypass conduits. Ann Thorac Surg. 2009 Mar; 87(3):748-56.
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26. Chung WB, Hamburg NM, Holbrook M, Shenouda SM, Dohadwala MM, Terry DF, Gokce N, Vita JA. The brachial artery remodels to maintain local shear stress despite the presence of cardiovascular risk factors. Arterioscler Thromb Vasc Biol. 2009 Apr; 29(4):606-12.
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27. Phinikaridou A, Hallock KJ, Qiao Y, Hamilton JA. A robust rabbit model of human atherosclerosis and atherothrombosis. J Lipid Res. 2009 May; 50(5):787-97.
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28. Blair P, Rex S, Vitseva O, Beaulieu L, Tanriverdi K, Chakrabarti S, Hayashi C, Genco CA, Iafrati M, Freedman JE. Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase. Circ Res. 2009 Feb 13; 104(3):346-54.
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29. Lacey DC, Simmons PJ, Graves SE, Hamilton JA. Proinflammatory cytokines inhibit osteogenic differentiation from stem cells: implications for bone repair during inflammation. Osteoarthritis Cartilage. 2009 Jun; 17(6):735-42.
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30. Qiao Y, Farber A, Semaan E, Hamilton JA. Images in cardiovascular medicine. Healing of an asymptomatic carotid plaque ulceration. Circulation. 2008 Sep 2; 118(10):e147-8.
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31. Gupta V, Bhasin S, Guo W, Singh R, Miki R, Chauhan P, Choong K, Tchkonia T, Lebrasseur NK, Flanagan JN, Hamilton JA, Viereck JC, Narula NS, Kirkland JL, Jasuja R. Effects of dihydrotestosterone on differentiation and proliferation of human mesenchymal stem cells and preadipocytes. Mol Cell Endocrinol. 2008 Dec 16; 296(1-2):32-40.
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32. Simard JR, Pillai BK, Hamilton JA. Fatty acid flip-flop in a model membrane is faster than desorption into the aqueous phase. Biochemistry. 2008 Sep 2; 47(35):9081-9.
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33. Simard JR, Kamp F, Hamilton JA. Measuring the adsorption of Fatty acids to phospholipid vesicles by multiple fluorescence probes. Biophys J. 2008 Jun; 94(11):4493-503.
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34. Izumiya Y, Hopkins T, Morris C, Sato K, Zeng L, Viereck J, Hamilton JA, Ouchi N, LeBrasseur NK, Walsh K. Fast/Glycolytic muscle fiber growth reduces fat mass and improves metabolic parameters in obese mice. Cell Metab. 2008 Feb; 7(2):159-72.
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35. Zhao LJ, Jiang H, Papasian CJ, Maulik D, Drees B, Hamilton J, Deng HW. Correlation of obesity and osteoporosis: effect of fat mass on the determination of osteoporosis. J Bone Miner Res. 2008 Jan; 23(1):17-29.
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36. Hamilton JA. New insights into the roles of proteins and lipids in membrane transport of fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2007 Nov-Dec; 77(5-6):355-61.
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37. Hamilton JA, Hillard CJ, Spector AA, Watkins PA. Brain uptake and utilization of fatty acids, lipids and lipoproteins: application to neurological disorders. J Mol Neurosci. 2007 Sep; 33(1):2-11.
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38. Hamilton JA, Brunaldi K. A model for fatty acid transport into the brain. J Mol Neurosci. 2007 Sep; 33(1):12-7.
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39. Watkins PA, Hamilton JA. Roundtable discussion of session 1: mechanisms of lipid uptake and transport in the brain. J Mol Neurosci. 2007 Sep; 33(1):45-50.
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40. Watkins PA, Hamilton JA. Roundtable discussion of session 2: lipoproteins and polyunsaturated fatty acids. J Mol Neurosci. 2007 Sep; 33(1):74-9.
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41. Watkins PA, Hamilton JA. Roundtable discussion of session 3: eicosanoids in brain function. J Mol Neurosci. 2007 Sep; 33(1):100-4.
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42. Watkins PA, Hamilton JA. Roundtable discussion of session 4: fatty acids and lipids in brain disorders. J Mol Neurosci. 2007 Sep; 33(1):120-4.
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43. Katz R, Hamilton JA, Pownall HJ, Deckelbaum RJ, Hillard CJ, Leboeuf RC, Watkins PA. Brain uptake and utilization of fatty acids, lipids & lipoproteins: recommendations for future research. J Mol Neurosci. 2007 Sep; 33(1):146-50.
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44. Duncanson WJ, Figa MA, Hallock K, Zalipsky S, Hamilton JA, Wong JY. Targeted binding of PLA microparticles with lipid-PEG-tethered ligands. Biomaterials. 2007 Nov; 28(33):4991-9.
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45. Ziouzenkova O, Orasanu G, Sharlach M, Akiyama TE, Berger JP, Viereck J, Hamilton JA, Tang G, Dolnikowski GG, Vogel S, Duester G, Plutzky J. Retinaldehyde represses adipogenesis and diet-induced obesity. Nat Med. 2007 Jun; 13(6):695-702.
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46. Qiao Y, Ronen I, Viereck J, Ruberg FL, Hamilton JA. Identification of atherosclerotic lipid deposits by diffusion-weighted imaging. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1440-6.
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47. Zhao LJ, Liu YJ, Liu PY, Hamilton J, Recker RR, Deng HW. Relationship of obesity with osteoporosis. J Clin Endocrinol Metab. 2007 May; 92(5):1640-6.
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48. Hamilton JA, Deckelbaum RJ. Crystal structure of CETP: new hopes for raising HDL to decrease risk of cardiovascular disease? Nat Struct Mol Biol. 2007 Feb; 14(2):95-7.
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49. Simard JR, Kamp F, Hamilton JA. Acrylodan-labeled intestinal fatty acid-binding protein to measure concentrations of unbound fatty acids. Methods Mol Biol. 2007; 400:27-43.
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50. Brunaldi K, Simard JR, Kamp F, Rewal C, Asawakarn T, O'Shea P, Hamilton JA. Fluorescence assays for measuring fatty acid binding and transport through membranes. Methods Mol Biol. 2007; 400:237-55.
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51. Hallock KJ, Hamilton JA. Ex vivo identification of atherosclerotic plaque calcification by a 31P solid-state magnetic resonance imaging technique. Magn Reson Med. 2006 Dec; 56(6):1380-3.
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52. Kamp F, Hamilton JA. How fatty acids of different chain length enter and leave cells by free diffusion. Prostaglandins Leukot Essent Fatty Acids. 2006 Sep; 75(3):149-59.
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53. Simard JR, Zunszain PA, Hamilton JA, Curry S. Location of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis. J Mol Biol. 2006 Aug 11; 361(2):336-51.
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54. Lücke C, Qiao Y, van Moerkerk HT, Veerkamp JH, Hamilton JA. Fatty-acid-binding protein from the flight muscle of Locusta migratoria: evolutionary variations in fatty acid binding. Biochemistry. 2006 May 23; 45(20):6296-305.
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55. Lücke C, Gantz DL, Klimtchuk E, Hamilton JA. Interactions between fatty acids and alpha-synuclein. J Lipid Res. 2006 Aug; 47(8):1714-24.
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56. Meshulam T, Simard JR, Wharton J, Hamilton JA, Pilch PF. Role of caveolin-1 and cholesterol in transmembrane fatty acid movement. Biochemistry. 2006 Mar 7; 45(9):2882-93.
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57. Xie W, Hamilton JA, Kirkland JL, Corkey BE, Guo W. Oleate-induced formation of fat cells with impaired insulin sensitivity. Lipids. 2006 Mar; 41(3):267-71.
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58. Simard JR, Zunszain PA, Ha CE, Yang JS, Bhagavan NV, Petitpas I, Curry S, Hamilton JA. Locating high-affinity fatty acid-binding sites on albumin by x-ray crystallography and NMR spectroscopy. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):17958-63.
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59. Ruberg FL, Viereck J, Phinikaridou A, Qiao Y, Loscalzo J, Hamilton JA. Identification of cholesteryl esters in human carotid atherosclerosis by ex vivo image-guided proton MRS. J Lipid Res. 2006 Feb; 47(2):310-7.
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60. Guo W, Huang N, Cai J, Xie W, Hamilton JA. Fatty acid transport and metabolism in HepG2 cells. Am J Physiol Gastrointest Liver Physiol. 2006 Mar; 290(3):G528-34.
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61. Guo W, Xie W, Lei T, Hamilton JA. Eicosapentaenoic acid, but not oleic acid, stimulates beta-oxidation in adipocytes. Lipids. 2005 Aug; 40(8):815-21.
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62. Skinner NA, MacIsaac CM, Hamilton JA, Visvanathan K. Regulation of Toll-like receptor (TLR)2 and TLR4 on CD14dimCD16+ monocytes in response to sepsis-related antigens. Clin Exp Immunol. 2005 Aug; 141(2):270-8.
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63. Viereck J, Ruberg FL, Qiao Y, Perez AS, Detwiller K, Johnstone M, Hamilton JA. MRI of atherothrombosis associated with plaque rupture. Arterioscler Thromb Vasc Biol. 2005 Jan; 25(1):240-5.
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64. Johnstone MT, Perez AS, Nasser I, Stewart R, Vaidya A, Al Ammary F, Schmidt B, Horowitz G, Dolgoff J, Hamilton J, Quist WC. Angiotensin receptor blockade with candesartan attenuates atherosclerosis, plaque disruption, and macrophage accumulation within the plaque in a rabbit model. Circulation. 2004 Oct 5; 110(14):2060-5.
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65. Hamilton JA. Fatty acid interactions with proteins: what X-ray crystal and NMR solution structures tell us. Prog Lipid Res. 2004 May; 43(3):177-99.
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66. Botnar RM, Perez AS, Witte S, Wiethoff AJ, Laredo J, Hamilton J, Quist W, Parsons EC, Vaidya A, Kolodziej A, Barrett JA, Graham PB, Weisskoff RM, Manning WJ, Johnstone MT. In vivo molecular imaging of acute and subacute thrombosis using a fibrin-binding magnetic resonance imaging contrast agent. Circulation. 2004 Apr 27; 109(16):2023-9.
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67. Lei T, Xie W, Han J, Corkey BE, Hamilton JA, Guo W. Medium-chain Fatty acids attenuate agonist-stimulated lipolysis, mimicking the effects of starvation. Obes Res. 2004 Apr; 12(4):599-611.
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68. Kamp F, Kizilbash N, Corkey BE, Berggren PO, Hamilton JA. Sulfonylureas rapidly cross phospholipid bilayer membranes by a free-diffusion mechanism. Diabetes. 2003 Oct; 52(10):2526-31.
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69. Pownall HJ, Hamilton JA. Energy translocation across cell membranes and membrane models. Acta Physiol Scand. 2003 Aug; 178(4):357-65.
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70. Zhang F, Lücke C, Baier LJ, Sacchettini JC, Hamilton JA. Solution structure of human intestinal fatty acid binding protein with a naturally-occurring single amino acid substitution (A54T) that is associated with altered lipid metabolism. Biochemistry. 2003 Jun 24; 42(24):7339-47.
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71. Hamilton JA. Fast flip-flop of cholesterol and fatty acids in membranes: implications for membrane transport proteins. Curr Opin Lipidol. 2003 Jun; 14(3):263-71.
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72. Han J, Hamilton JA, Kirkland JL, Corkey BE, Guo W. Medium-chain oil reduces fat mass and down-regulates expression of adipogenic genes in rats. Obes Res. 2003 Jun; 11(6):734-44.
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73. Lücke C, Kizilbash N, van Moerkerk HT, Veerkamp JH, Hamilton JA. NMR assignment and structural characterization of the fatty acid binding protein from the flight muscle of Locusta migratoria. J Biomol NMR. 2003 Apr; 25(4):355-6.
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74. Sharon R, Bar-Joseph I, Frosch MP, Walsh DM, Hamilton JA, Selkoe DJ. The formation of highly soluble oligomers of alpha-synuclein is regulated by fatty acids and enhanced in Parkinson's disease. Neuron. 2003 Feb 20; 37(4):583-95.
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75. Johnson RA, Hamilton JA, Worgall TS, Deckelbaum RJ. Free fatty acids modulate intermembrane trafficking of cholesterol by increasing lipid mobilities: novel 13C NMR analyses of free cholesterol partitioning. Biochemistry. 2003 Feb 18; 42(6):1637-45.
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76. Kamp F, Guo W, Souto R, Pilch PF, Corkey BE, Hamilton JA. Rapid flip-flop of oleic acid across the plasma membrane of adipocytes. J Biol Chem. 2003 Mar 7; 278(10):7988-95.
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77. Hamilton JA, Guo W, Kamp F. Mechanism of cellular uptake of long-chain fatty acids: Do we need cellular proteins? Mol Cell Biochem. 2002 Oct; 239(1-2):17-23.
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78. Guo W, Kurze V, Huber T, Afdhal NH, Beyer K, Hamilton JA. A solid-state NMR study of phospholipid-cholesterol interactions: sphingomyelin-cholesterol binary systems. Biophys J. 2002 Sep; 83(3):1465-78.
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79. Ho JK, Duclos RI, Hamilton JA. Interactions of acyl carnitines with model membranes: a (13)C-NMR study. J Lipid Res. 2002 Sep; 43(9):1429-39.
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80. Hamilton JA. How fatty acids bind to proteins: the inside story from protein structures. Prostaglandins Leukot Essent Fatty Acids. 2002 Aug-Sep; 67(2-3):65-72.
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81. Choi JK, Ho J, Curry S, Qin D, Bittman R, Hamilton JA. Interactions of very long-chain saturated fatty acids with serum albumin. J Lipid Res. 2002 Jul; 43(7):1000-10.
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82. McMahon KA, Wilson NJ, Marks DC, Beecroft TL, Whitty GA, Hamilton JA, Csar XF. Colony-stimulating factor-1 (CSF-1) receptor-mediated macrophage differentiation in myeloid cells: a role for tyrosine 559-dependent protein phosphatase 2A (PP2A) activity. Biochem J. 2001 Sep 1; 358(Pt 2):431-6.
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83. Johnstone MT, Botnar RM, Perez AS, Stewart R, Quist WC, Hamilton JA, Manning WJ. In vivo magnetic resonance imaging of experimental thrombosis in a rabbit model. Arterioscler Thromb Vasc Biol. 2001 Sep; 21(9):1556-60.
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84. Hamilton JA, Benson MD. Transthyretin: a review from a structural perspective. Cell Mol Life Sci. 2001 Sep; 58(10):1491-521.
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85. Yang YH, Carmeliet P, Hamilton JA. Tissue-type plasminogen activator deficiency exacerbates arthritis. J Immunol. 2001 Jul 15; 167(2):1047-52.
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86. Katz R, Hamilton JA, Spector AA, Moore SA, Moser HW, Noetzel MJ, Watkins PA. Brain uptake and utilization of fatty acids: recommendations for future research. J Mol Neurosci. 2001 Apr-Jun; 16(2-3):333-5.
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87. Watkins PA, Hamilton JA, Leaf A, Spector AA, Moore SA, Anderson RE, Moser HW, Noetzel MJ, Katz R. Brain uptake and utilization of fatty acids: applications to peroxisomal biogenesis diseases. J Mol Neurosci. 2001 Apr-Jun; 16(2-3):87-92; discussion 151-7.
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88. Hamilton JA, Johnson RA, Corkey B, Kamp F. Fatty acid transport: the diffusion mechanism in model and biological membranes. J Mol Neurosci. 2001 Apr-Jun; 16(2-3):99-108; discussion 151-7.
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89. Hamilton JA, Jessup W, Brown AJ, Whitty G. Enhancement of macrophage survival and DNA synthesis by oxidized-low-density-lipoprotein (LDL)-derived lipids and by aggregates of lightly oxidized LDL. Biochem J. 2001 Apr 1; 355(Pt 1):207-14.
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90. Caserta F, Tchkonia T, Civelek VN, Prentki M, Brown NF, McGarry JD, Forse RA, Corkey BE, Hamilton JA, Kirkland JL. Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes. Am J Physiol Endocrinol Metab. 2001 Feb; 280(2):E238-47.
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91. Ek-Von Mentzer BA, Zhang F, Hamilton JA. Binding of 13-HODE and 15-HETE to phospholipid bilayers, albumin, and intracellular fatty acid binding proteins. implications for transmembrane and intracellular transport and for protection from lipid peroxidation. J Biol Chem. 2001 May 11; 276(19):15575-80.
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92. Yaney GC, Civelek VN, Richard AM, Dillon JS, Deeney JT, Hamilton JA, Korchak HM, Tornheim K, Corkey BE, Boyd AE. Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT). Diabetes. 2001 Jan; 50(1):56-62.
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93. Peng S, Guo W, Morrisett JD, Johnstone MT, Hamilton JA. Quantification of cholesteryl esters in human and rabbit atherosclerotic plaques by magic-angle spinning (13)C-NMR. Arterioscler Thromb Vasc Biol. 2000 Dec; 20(12):2682-8.
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94. Hamilton JA, Whitty G, Jessup W. Oxidized LDL can promote human monocyte survival. Arterioscler Thromb Vasc Biol. 2000 Oct; 20(10):2329-31.
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95. Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA. Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate. Biochem J. 2000 Jul 15; 349(Pt 2):463-71.
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96. Guo W, Morrisett JD, DeBakey ME, Lawrie GM, Hamilton JA. Quantification in situ of crystalline cholesterol and calcium phosphate hydroxyapatite in human atherosclerotic plaques by solid-state magic angle spinning NMR. Arterioscler Thromb Vasc Biol. 2000 Jun; 20(6):1630-6.
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97. Lücke C, Zhang F, Hamilton JA, Sacchettini JC, Rüterjans H. Solution structure of ileal lipid binding protein in complex with glycocholate. Eur J Biochem. 2000 May; 267(10):2929-38.
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98. Fowles LF, Stacey KJ, Marks D, Hamilton JA, Hume DA. Regulation of urokinase plasminogen activator gene transcription in the RAW264 murine macrophage cell line by macrophage colony-stimulating factor (CSF-1) is dependent upon the level of cell-surface receptor. Biochem J. 2000 Apr 1; 347 Pt 1:313-20.
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99. Hamilton JA, Kamp F. How are free fatty acids transported in membranes? Is it by proteins or by free diffusion through the lipids? Diabetes. 1999 Dec; 48(12):2255-69.
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100. Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA. Incorporation of [1-13C]oleate into cellular triglycerides in differentiating 3T3L1 cells. Lipids. 1999 Aug; 34(8):825-31.
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101. Hamilton JA. Transport of fatty acids across membranes by the diffusion mechanism. Prostaglandins Leukot Essent Fatty Acids. 1999 May-Jun; 60(5-6):291-7.
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102. Lücke C, Fushman D, Ludwig C, Hamilton JA, Sacchettini JC, Rüterjans H. A comparative study of the backbone dynamics of two closely related lipid binding proteins: bovine heart fatty acid binding protein and porcine ileal lipid binding protein. Mol Cell Biochem. 1999 Feb; 192(1-2):109-21.
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103. Hamilton JA, Myers D, Jessup W, Cochrane F, Byrne R, Whitty G, Moss S. Oxidized LDL can induce macrophage survival, DNA synthesis, and enhanced proliferative response to CSF-1 and GM-CSF. Arterioscler Thromb Vasc Biol. 1999 Jan; 19(1):98-105.
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104. Hamilton JA, Chan J, Byrne RJ, Bischof RJ, Jaworowski A, Kanagasundaram V. MRL/lpr and MRL+/+ macrophage DNA synthesis in the absence and the presence of colony-stimulating factor-1 and granulocyte-macrophage colony-stimulating factor. J Immunol. 1998 Dec 15; 161(12):6802-11.
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105. Campbell IK, Rich MJ, Bischof RJ, Dunn AR, Grail D, Hamilton JA. Protection from collagen-induced arthritis in granulocyte-macrophage colony-stimulating factor-deficient mice. J Immunol. 1998 Oct 1; 161(7):3639-44.
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106. Guo W, Kirkland JL, Corkey B, Hamilton JA. A 13C nuclear magnetic resonance study of free fatty acid incorporation in acylated lipids in differentiating preadipocytes. Lipids. 1998 May; 33(5):449-54.
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107. Hamilton JA. Fatty acid transport: difficult or easy? J Lipid Res. 1998 Mar; 39(3):467-81.
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108. Kanagasundaram V, Christy E, Hamilton JA, Jaworowski A. Different pathways of colony-stimulating factor 1 degradation in macrophage populations revealed by wortmannin sensitivity. Biochem J. 1998 Feb 15; 330 ( Pt 1):197-202.
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109. Guo W, Morrisett JD, Lawrie GM, DeBakey ME, Hamilton JA. Identification of different lipid phases and calcium phosphate deposits in human carotid artery plaques by MAS NMR spectroscopy. Magn Reson Med. 1998 Feb; 39(2):184-9.
  View in: PubMed
 
110. Vadiveloo PK, Filonzi EL, Stanton HR, Hamilton JA. G1 phase arrest of human smooth muscle cells by heparin, IL-4 and cAMP is linked to repression of cyclin D1 and cdk2. Atherosclerosis. 1997 Aug; 133(1):61-9.
  View in: PubMed
 
111. Ek BA, Cistola DP, Hamilton JA, Kaduce TL, Spector AA. Fatty acid binding proteins reduce 15-lipoxygenase-induced oxygenation of linoleic acid and arachidonic acid. Biochim Biophys Acta. 1997 May 17; 1346(1):75-85.
  View in: PubMed
 
112. Zhang F, Lücke C, Baier LJ, Sacchettini JC, Hamilton JA. Solution structure of human intestinal fatty acid binding protein: implications for ligand entry and exit. J Biomol NMR. 1997 Apr; 9(3):213-28.
  View in: PubMed
 
113. Csar XF, Ward AC, Hoffmann BW, Guy GG, Hamilton JA. Identification of phosphoproteins specific to granulocyte colony-stimulating factor-mediated signaling using 2D-SDS-PAGE. J Interferon Cytokine Res. 1997 Feb; 17(2):77-86.
  View in: PubMed
 
114. Hamilton JA. CSF-1 and cell cycle control in macrophages. Mol Reprod Dev. 1997 Jan; 46(1):19-23.
  View in: PubMed
 
115. Zhang F, Kamp F, Hamilton JA. Dissociation of long and very long chain fatty acids from phospholipid bilayers. Biochemistry. 1996 Dec 17; 35(50):16055-60.
  View in: PubMed
 
116. Kanagasundaram V, Jaworowski A, Hamilton JA. Association between phosphatidylinositol-3 kinase, Cbl and other tyrosine phosphorylated proteins in colony-stimulating factor-1-stimulated macrophages. Biochem J. 1996 Nov 15; 320 ( Pt 1):69-77.
  View in: PubMed
 
117. Guo W, Hamilton JA. 13C MAS NMR studies of crystalline cholesterol and lipid mixtures modeling atherosclerotic plaques. Biophys J. 1996 Nov; 71(5):2857-68.
  View in: PubMed
 
118. Ward AC, Hoffmann BW, Csar XF, Hamilton JA. Granulocyte colony-stimulating factor-stimulated proliferation of myeloid cells: mode of cell cycle control by a range of inhibitors. J Interferon Cytokine Res. 1996 Oct; 16(10):869-77.
  View in: PubMed
 
119. Civelek VN, Hamilton JA, Tornheim K, Kelly KL, Corkey BE. Intracellular pH in adipocytes: effects of free fatty acid diffusion across the plasma membrane, lipolytic agonists, and insulin. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10139-44.
  View in: PubMed
 
120. Gavin AL, Hamilton JA, Hogarth PM. Extracellular mutations of non-obese diabetic mouse FcgammaRI modify surface expression and ligand binding. J Biol Chem. 1996 Jul 19; 271(29):17091-9.
  View in: PubMed
 
121. Lücke C, Zhang F, Rüterjans H, Hamilton JA, Sacchettini JC. Flexibility is a likely determinant of binding specificity in the case of ileal lipid binding protein. Structure. 1996 Jul 15; 4(7):785-800.
  View in: PubMed
 
122. Bird DA, Laposata M, Hamilton JA. Binding of ethyl oleate to low density lipoprotein, phospholipid vesicles, and albumin: a 13C NMR study. J Lipid Res. 1996 Jul; 37(7):1449-58.
  View in: PubMed
 
123. Udagawa N, Chan J, Wada S, Findlay DM, Hamilton JA, Martin TJ. c-fos antisense DNA inhibits proliferation of osteoclast progenitors in osteoclast development but not macrophage differentiation in vitro. Bone. 1996 Jun; 18(6):511-6.
  View in: PubMed
 
124. Boyle E, Small DM, Gantz D, Hamilton JA, German JB. Monoacylglycerols alter the lipid composition and molecular mobility of phosphatidylcholine bilayers: 13C NMR evidence of dynamic lipid remodeling. J Lipid Res. 1996 Apr; 37(4):764-72.
  View in: PubMed
 
125. Hamilton JA, Vural JM, Carpentier YA, Deckelbaum RJ. Incorporation of medium chain triacylglycerols into phospholipid bilayers: effect of long chain triacylglycerols, cholesterol, and cholesteryl esters. J Lipid Res. 1996 Apr; 37(4):773-82.
  View in: PubMed
 
126. Salmon A, Hamilton JA. Magic-angle spinning and solution 13C nuclear magnetic resonance studies of medium- and long-chain cholesteryl esters in model bilayers. Biochemistry. 1995 Dec 12; 34(49):16065-73.
  View in: PubMed
 
127. Guo W, Hamilton JA. A multinuclear solid-state NMR study of phospholipid-cholesterol interactions. Dipalmitoylphosphatidylcholine-cholesterol binary system. Biochemistry. 1995 Oct 31; 34(43):14174-84.
  View in: PubMed
 
128. Kamp F, Zakim D, Zhang F, Noy N, Hamilton JA. Fatty acid flip-flop in phospholipid bilayers is extremely fast. Biochemistry. 1995 Sep 19; 34(37):11928-37.
  View in: PubMed
 
129. Ho JK, Moser H, Kishimoto Y, Hamilton JA. Interactions of a very long chain fatty acid with model membranes and serum albumin. Implications for the pathogenesis of adrenoleukodystrophy. J Clin Invest. 1995 Sep; 96(3):1455-63.
  View in: PubMed
 
130. Guo W, Hamilton JA. Phase behavior and crystalline structures of cholesteryl ester mixtures: a C-13 MASNMR study. Biophys J. 1995 Jun; 68(6):2376-86.
  View in: PubMed
 
131. Bhamidipati SP, Hamilton JA. Interactions of lyso 1-palmitoylphosphatidylcholine with phospholipids: a 13C and 31P NMR study. Biochemistry. 1995 Apr 25; 34(16):5666-77.
  View in: PubMed
 
132. Guo W, Hamilton JA. Molecular organization and motions of crystalline monoacylglycerols and diacylglycerols: a C-13 MASNMR study. Biophys J. 1995 Apr; 68(4):1383-95.
  View in: PubMed
 
133. Petrou S, Ordway RW, Kirber MT, Dopico AM, Hamilton JA, Walsh JV, Singer JJ. Direct effects of fatty acids and other charged lipids on ion channel activity in smooth muscle cells. Prostaglandins Leukot Essent Fatty Acids. 1995 Feb-Mar; 52(2-3):173-8.
  View in: PubMed
 
134. Hamilton JA, Civelek VN, Kamp F, Tornheim K, Corkey BE. Changes in internal pH caused by movement of fatty acids into and out of clonal pancreatic beta-cells (HIT). J Biol Chem. 1994 Aug 19; 269(33):20852-6.
  View in: PubMed
 
135. Ko J, Hamilton JA, Ton-Nu HT, Schteingart CD, Hofmann AF, Small DM. Effects of side chain length on ionization behavior and transbilayer transport of unconjugated dihydroxy bile acids: a comparison of nor-chenodeoxycholic acid and chenodeoxycholic acid. J Lipid Res. 1994 May; 35(5):883-92.
  View in: PubMed
 
136. Petrou S, Ordway RW, Hamilton JA, Walsh JV, Singer JJ. Structural requirements for charged lipid molecules to directly increase or suppress K+ channel activity in smooth muscle cells. Effects of fatty acids, lysophosphatidate, acyl coenzyme A and sphingosine. J Gen Physiol. 1994 Mar; 103(3):471-86.
  View in: PubMed
 
137. Kenyon MA, Hamilton JA. 13C NMR studies of the binding of medium-chain fatty acids to human serum albumin. J Lipid Res. 1994 Mar; 35(3):458-67.
  View in: PubMed
 
138. Kamp F, Hamilton JA, Kamp F, Westerhoff HV, Hamilton JA. Movement of fatty acids, fatty acid analogues, and bile acids across phospholipid bilayers. Biochemistry. 1993 Oct 19; 32(41):11074-86.
  View in: PubMed
 
139. Fosang AJ, Last K, Knäuper V, Neame PJ, Murphy G, Hardingham TE, Tschesche H, Hamilton JA. Fibroblast and neutrophil collagenases cleave at two sites in the cartilage aggrecan interglobular domain. Biochem J. 1993 Oct 1; 295 ( Pt 1):273-6.
  View in: PubMed
 
140. Guo W, Hamilton JA. Molecular organization and motions of cholesteryl esters in crystalline and liquid crystalline phases: a 13C and 1H magic angle spinning NMR study. Biochemistry. 1993 Sep 7; 32(35):9038-52.
  View in: PubMed
 
141. Hudson NW, Albrecht M, Randhawa ZI, Steinrauf LK, Hamilton JA. Regeneration of antidigoxin binding activity in an antibody by changes surrounding the original binding defect. Mol Immunol. 1993 May; 30(7):685-93.
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142. Filonzi EL, Zoellner H, Stanton H, Hamilton JA. Cytokine regulation of granulocyte-macrophage colony stimulating factor and macrophage colony-stimulating factor production in human arterial smooth muscle cells. Atherosclerosis. 1993 Mar; 99(2):241-52.
  View in: PubMed
 
143. Hamilton JA, Steinrauf LK, Braden BC, Liepnieks J, Benson MD, Holmgren G, Sandgren O, Steen L. The x-ray crystal structure refinements of normal human transthyretin and the amyloidogenic Val-30-->Met variant to 1.7-A resolution. J Biol Chem. 1993 Feb 5; 268(4):2416-24.
  View in: PubMed
 
144. Bhamidipati SP, Hamilton JA. NMR studies of phospholipase C hydrolysis of phosphatidylcholine in model membranes. J Biol Chem. 1993 Feb 5; 268(4):2431-4.
  View in: PubMed
 
145. Elliott MJ, Faulkner-Jones BE, Stanton H, Hamilton JA, Metcalf D. Plasminogen activator in granulocyte-macrophage-CSF transgenic mice. J Immunol. 1992 Dec 1; 149(11):3678-81.
  View in: PubMed
 
146. Kamp F, Hamilton JA. pH gradients across phospholipid membranes caused by fast flip-flop of un-ionized fatty acids. Proc Natl Acad Sci U S A. 1992 Dec 1; 89(23):11367-70.
  View in: PubMed
 
147. Smith SO, Kustanovich I, Bhamidipati S, Salmon A, Hamilton JA. Interfacial conformation of dipalmitoylglycerol and dipalmitoylphosphatidylcholine in phospholipid bilayers. Biochemistry. 1992 Nov 24; 31(46):11660-4.
  View in: PubMed
 
148. Hamilton JA, Vairo G, Cocks BG. Inhibition of S-phase progression in macrophages is linked to G1/S-phase suppression of DNA synthesis genes. J Immunol. 1992 Jun 15; 148(12):4028-35.
  View in: PubMed
 
149. Boylan JG, Hamilton JA. Interactions of acyl-coenzyme A with phosphatidylcholine bilayers and serum albumin. Biochemistry. 1992 Jan 21; 31(2):557-67.
  View in: PubMed
 
150. Bhaskar KR, Gong DH, Bansil R, Pajevic S, Hamilton JA, Turner BS, LaMont JT. Profound increase in viscosity and aggregation of pig gastric mucin at low pH. Am J Physiol. 1991 Nov; 261(5 Pt 1):G827-32.
  View in: PubMed
 
151. Hamilton JA, Piccoli DS, Leizer T, Butler DM, Croatto M, Royston AK. Transforming growth factor beta stimulates urokinase-type plasminogen activator and DNA synthesis, but not prostaglandin E2 production, in human synovial fibroblasts. Proc Natl Acad Sci U S A. 1991 Aug 15; 88(16):7180-4.
  View in: PubMed
 
152. Deshpande MS, Boylan J, Hamilton JA, Burton J. Conformation and inhibitory properties of peptides based on the tissue kallikrein-aprotinin complex. Int J Pept Protein Res. 1991 Jun; 37(6):536-43.
  View in: PubMed
 
153. Hamilton JA, Fujito DT, Hammer CF. Solubilization and localization of weakly polar lipids in unsonicated egg phosphatidylcholine: A 13C MAS NMR study. Biochemistry. 1991 Mar 19; 30(11):2894-902.
  View in: PubMed
 
154. Hamilton JA, Era S, Bhamidipati SP, Reed RG. Locations of the three primary binding sites for long-chain fatty acids on bovine serum albumin. Proc Natl Acad Sci U S A. 1991 Mar 15; 88(6):2051-4.
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155. Hamilton JA, Bhamidipati SP, Kodali DR, Small DM. The interfacial conformation and transbilayer movement of diacylglycerols in phospholipid bilayers. J Biol Chem. 1991 Jan 15; 266(2):1177-86.
  View in: PubMed
 
156. Hudson NW, Bruccoleri RE, Steinrauf LK, Hamilton JA, Mudgett-Hunter M, Margolies MN. A V kappa-J kappa junctional change in an antidigoxin recombinant antibody destroys digoxin-binding activity. J Immunol. 1990 Oct 15; 145(8):2718-24.
  View in: PubMed
 
157. Vairo G, Argyriou S, Bordun AM, Gonda TJ, Cragoe EJ, Hamilton JA. Na+/H+ exchange involvement in colony-stimulating factor-1-stimulated macrophage proliferation. Evidence for a requirement during late G1 of the cell cycle but not for early growth factor responses. J Biol Chem. 1990 Oct 5; 265(28):16929-39.
  View in: PubMed
 
158. Spooner PJ, Gantz DL, Hamilton JA, Small DM. The distribution of oleic acid between chylomicron-like emulsions, phospholipid bilayers, and serum albumin. A model for fatty acid distribution between lipoproteins, membranes, and albumin. J Biol Chem. 1990 Jul 25; 265(21):12650-5.
  View in: PubMed
 
159. Deckelbaum RJ, Hamilton JA, Moser A, Bengtsson-Olivecrona G, Butbul E, Carpentier YA, Gutman A, Olivecrona T. Medium-chain versus long-chain triacylglycerol emulsion hydrolysis by lipoprotein lipase and hepatic lipase: implications for the mechanisms of lipase action. Biochemistry. 1990 Feb 6; 29(5):1136-42.
  View in: PubMed
 
160. Bhamidipati SP, Hamilton JA. Hydrolysis of a phospholipid in an inert lipid matrix by phospholipase A2: a 13C NMR study. Biochemistry. 1989 Aug 8; 28(16):6667-72.
  View in: PubMed
 
161. Hamilton JA. Medium-chain fatty acid binding to albumin and transfer to phospholipid bilayers. Proc Natl Acad Sci U S A. 1989 Apr; 86(8):2663-7.
  View in: PubMed
 
162. Hamilton JA. Interactions of triglycerides with phospholipids: incorporation into the bilayer structure and formation of emulsions. Biochemistry. 1989 Mar 21; 28(6):2514-20.
  View in: PubMed
 
163. Cistola DP, Hamilton JA, Jackson D, Small DM. Ionization and phase behavior of fatty acids in water: application of the Gibbs phase rule. Biochemistry. 1988 Mar 22; 27(6):1881-8.
  View in: PubMed
 
164. Cistola DP, Walsh MT, Corey RP, Hamilton JA, Brecher P. Interactions of oleic acid with liver fatty acid binding protein: a carbon-13 NMR study. Biochemistry. 1988 Jan 26; 27(2):711-7.
  View in: PubMed
 
165. Spooner PJ, Clark SB, Gantz DL, Hamilton JA, Small DM. The ionization and distribution behavior of oleic acid in chylomicrons and chylomicron-like emulsion particles and the influence of serum albumin. J Biol Chem. 1988 Jan 25; 263(3):1444-53.
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166. Walsh MT, Hamilton JA, Atkinson D, Small DM. Secondary and tertiary structure of apolipoproteins. Adv Exp Med Biol. 1988; 243:123-32.
  View in: PubMed
 
167. Croll DH, Sripada PK, Hamilton JA. Temperature-dependent molecular motions and phase behavior of cholesteryl ester analogues. J Lipid Res. 1987 Dec; 28(12):1444-54.
  View in: PubMed
 
168. Cistola DP, Small DM, Hamilton JA. Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. I. The filling of individual fatty acid binding sites. J Biol Chem. 1987 Aug 15; 262(23):10971-9.
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169. Cistola DP, Small DM, Hamilton JA. Carbon 13 NMR studies of saturated fatty acids bound to bovine serum albumin. II. Electrostatic interactions in individual fatty acid binding sites. J Biol Chem. 1987 Aug 15; 262(23):10980-5.
  View in: PubMed
 
170. Sripada PK, Maulik PR, Hamilton JA, Shipley GG. Partial synthesis and properties of a series of N-acyl sphingomyelins. J Lipid Res. 1987 Jun; 28(6):710-8.
  View in: PubMed
 
171. Cabral DJ, Small DM, Lilly HS, Hamilton JA. Transbilayer movement of bile acids in model membranes. Biochemistry. 1987 Apr 7; 26(7):1801-4.
  View in: PubMed
 
172. Spooner PJ, Hamilton JA, Gantz DL, Small DM. The effect of free cholesterol on the solubilization of cholesteryl oleate in phosphatidylcholine bilayers: A 13C-NMR study. Biochim Biophys Acta. 1986 Aug 21; 860(2):345-53.
  View in: PubMed
 
173. Cistola DP, Atkinson D, Hamilton JA, Small DM. Phase behavior and bilayer properties of fatty acids: hydrated 1:1 acid-soaps. Biochemistry. 1986 May 20; 25(10):2804-12.
  View in: PubMed
 
174. Cabral DJ, Hamilton JA, Small DM. The ionization behavior of bile acids in different aqueous environments. J Lipid Res. 1986 Mar; 27(3):334-43.
  View in: PubMed
 
175. Hamilton JA, Cistola DP. Transfer of oleic acid between albumin and phospholipid vesicles. Proc Natl Acad Sci U S A. 1986 Jan; 83(1):82-6.
  View in: PubMed
 
176. Hamilton JA, Morrisett JD. Nuclear magnetic resonance studies of lipoproteins. Methods Enzymol. 1986; 128:472-515.
  View in: PubMed
 
177. Croll DH, Small DM, Hamilton JA. Molecular motions and thermotropic phase behavior of cholesteryl esters with triolein. Biochemistry. 1985 Dec 31; 24(27):7971-80.
  View in: PubMed
 
178. Morrisett JD, Gaubatz JW, Tarver AP, Allen JK, Pownall HJ, Laggner P, Hamilton JA. Thermotropic properties and molecular dynamics of cholesteryl ester rich very low density lipoproteins: effect of hydrophobic core on polar surface. Biochemistry. 1984 Oct 23; 23(22):5343-52.
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179. Small DM, Cabral DJ, Cistola DP, Parks JS, Hamilton JA. The ionization behavior of fatty acids and bile acids in micelles and membranes. Hepatology. 1984 Sep-Oct; 4(5 Suppl):77S-79S.
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180. Hamilton JA, Cistola DP, Morrisett JD, Sparrow JT, Small DM. Interactions of myristic acid with bovine serum albumin: a 13C NMR study. Proc Natl Acad Sci U S A. 1984 Jun; 81(12):3718-22.
  View in: PubMed
 
181. Hamilton JA, Miller KW, Small DM. Solubilization of triolein and cholesteryl oleate in egg phosphatidylcholine vesicles. J Biol Chem. 1983 Nov 10; 258(21):12821-6.
  View in: PubMed
 
182. Parks JS, Cistola DP, Small DM, Hamilton JA. Interactions of the carboxyl group of oleic acid with bovine serum albumin: a 13C NMR study. J Biol Chem. 1983 Aug 10; 258(15):9262-9.
  View in: PubMed
 
183. Hamilton JA, Small DM, Parks JS. 1H NMR studies of lymph chylomicra and very low density lipoproteins from nonhuman primates. J Biol Chem. 1983 Jan 25; 258(2):1172-9.
  View in: PubMed
 
184. Ginsburg GS, Small DM, Hamilton JA. Temperature-dependent molecular motions of cholesterol esters: a carbon-13 nuclear magnetic resonance study. Biochemistry. 1982 Dec 21; 21(26):6857-67.
  View in: PubMed
 
185. Hamilton JA, Small DM. Solubilization and localization of cholesteryl oleate in egg phosphatidylcholine vesicles. A carbon 13 NMR study. J Biol Chem. 1982 Jul 10; 257(13):7318-21.
  View in: PubMed
 
186. Cistola DP, Small DM, Hamilton JA. Ionization behavior of aqueous short-chain carboxylic acids: a carbon-13 NMR study. J Lipid Res. 1982 Jul; 23(5):795-9.
  View in: PubMed
 
187. Hamilton JA, Zabriskie JB, Lachman LB, Chen YS. Streptococcal cell walls and synovial cell activation. Stimulation of synovial fibroblast plasminogen activator activity by monocytes treated with group A streptococcal cell wall sonicates and muramyl dipeptide. J Exp Med. 1982 Jun 1; 155(6):1702-18.
  View in: PubMed
 
188. Clark SB, Atkinson D, Hamilton JA, Forte T, Russell B, Feldman EB, Small DM. Physical studies of d less than 1.006 g/ml lymph lipoproteins from rats fed palmitate-rich diets. J Lipid Res. 1982 Jan; 23(1):28-41.
  View in: PubMed
 
189. Hamilton JA, Small DM. Solubilization and localization of triolein in phosphatidylcholine bilayers: a 13C NMR study. Proc Natl Acad Sci U S A. 1981 Nov; 78(11):6878-82.
  View in: PubMed
 
190. Brainard JR, Hamilton JA, Cordes EH, Patsch JR, Gotto AM, Morrisett JD. Lipoprotein-X: carbon-13 nuclear magnetic resonance studies on native, reconstituted, and model systems. Biochemistry. 1980 Sep 2; 19(18):4266-73.
  View in: PubMed
 
191. Hamilton JA, Cordes EH, Glueck CJ. Lipid dynamics in human low density lipoproteins and human aortic tissue with fibrous plaques. A study by high field 13C NMR spectroscopy. J Biol Chem. 1979 Jun 25; 254(12):5435-41.
  View in: PubMed
 
192. Hamilton JA, Cordes EH. Molecular dynamics of lipids in human plasma high density lipoproteins. A high field 13C NMR study. J Biol Chem. 1978 Jul 25; 253(14):5193-8.
  View in: PubMed
 
193. Avila EM, Hamilton JA, Harmony JA, Allerhand A, Cordes EH. Natural abundance 13C nuclear magnetic resonance studies of human plasma high density lipoproteins. J Biol Chem. 1978 Jun 10; 253(11):3983-7.
  View in: PubMed
 
194. Hamilton JA, Oppenheimer N, Cordes EH. Carbon-13 nuclear magnetic resonance studies of cholesteryl esters and cholesteryl ester/triglyceride mixtures. J Biol Chem. 1977 Nov 25; 252(22):8071-80.
  View in: PubMed
 
195. Hamilton JA, Oppenheimer NJ, Addleman R, Clouse AO, Cordes EH, Steiner PM, Glueck CJ. High-field 13C NMR Studies of certain normal and abnormal human plasma lipoproteins. Science. 1976 Dec 24; 194(4272):1424-7.
  View in: PubMed
 
196. Hamilton JA, Miller JF. Hapten-specific tolerance in mice. I. Induction with hapten-coupled syngeneic erythrocytes. Eur J Immunol. 1974 Apr; 4(4):261-8.
  View in: PubMed
 
197. Hamilton JA, Miller JF, Kettman J. Hapten-specific tolerance in mice. II. Adoptive transfer studies and evidence for unresponsiveness in the B cells. Eur J Immunol. 1974 Apr; 4(4):268-76.
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198. Hamilton JA, Miller JF. Induction of a primary antihapten response in vivo by a graft-vs.-host reaction. J Exp Med. 1973 Oct 1; 138(4):1009-14.
  View in: PubMed
 
199. Williams E, Hamilton JA, Jain MK, Allerhand A, Cordes EH, Ochs S. Natural abundance carbon-13 nuclear magnetic resonance spectra of the canine sciatic nerve. Science. 1973 Aug 31; 181(102):869-71.
  View in: PubMed
 
200. Hamilton JA, Miller JF. Hapten-specific tolerance: unresponsiveness in the T cell-depleted population. Eur J Immunol. 1973 Jul; 3(7):457-60.
  View in: PubMed
 
201. Hamilton JA, Talkowski C, Williams E, Avila EM, Allerhand A, Cordes EH, Camejo G. Natural abundance carbon-13 nuclear magnetic resonance spectra of human serum lipoproteins. Science. 1973 Apr 15; 180(82):193-5.
  View in: PubMed
 
202. Young IG, Leppik RA, Hamilton JA, Gibson F. Biochemical and genetic studies on ubiquinone biosynthesis in Escherichia coli K-12:4-hydroxybenzoate octaprenyltransferase. J Bacteriol. 1972 Apr; 110(1):18-25.
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203. Cox GB, Newton NA, Gibson F, Snoswell AM, Hamilton JA. The function of ubiquinone in Escherichia coli. Biochem J. 1970 Apr; 117(3):551-62.
  View in: PubMed
 
204. Hamilton JA, Cox GB, Looney FD, Gibson F. Ubisemiquinone in membranes from Escherichia coli. Biochem J. 1970 Jan; 116(2):319-20.
  View in: PubMed
 
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Keyword
Last Name
Institution
Division
    
 
 
 
Keywords   
Fatty Acids
Lipid Bilayers
Magnetic Resonance Spectroscopy
Phospholipids
Cell Membrane
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Co-Authors  
Corkey, Barbara
Guo, Wen
Hallock, Kevin
Ruberg, Frederick
Small, Donald
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